The Human Genetics Foundation (HuGeF) is a private not-for-profit institution established by the Foundation Compagnia di San Paolo, the University of Turin and the Turin Polytechnic. The mission of HuGeF is to promote basic and translational research and post-graduate training in scientific disciplines related to human genetics, genomics and epigenomics in a multi-disciplinary and integrated environment, with special but not exclusive reference to multifactorial diseases. The laboratories, located in Torino, Italy, started their activities in 2010 and they are currently composed of around 50 staff divided in five research groups: Genomic Variation in Human Populations and Complex Diseases, Molecular and Genetic Epidemiology, Immunogenetics, Epigenetics, and Statistical Inference and Computational Biology. Research staff includes molecular biologists, epidemiologists, geneticists, biostatisticians, bioinformaticians, physicists, and mathematicians. HuGeF’s advanced technological platforms dedicated to microarray, sequencing, cytofluorimetry, microscopy, and cytogenetic analyses are available to research staff and collaborators.